All about Microsoft's Mary Jo Foley reports that AutoCAD and other Autodesk software requires patching to work with Vista. In Vista: Where are the killer apps?, she writes:
Autodesk officials say their current core CAD applications are working with Vista after applying downloadable patches.
She confirms that DWF is not native to Vista:
The next version of Autodesk's core products "will put DWF data in an XPS wrapper," [Autodesk Senior Director Kevin] Wandryk said. (XPS is Microsoft's alternative to Adobe's PDF technology.)